To prepare a stuffed meat loaf ii beef recipe, you will first need to prepare the ingredients for the recipe. Place the ground beef, bread crumbs, onion powder, Worcestershire sauce, salt, pepper, and thyme in the large bowl. Toss to coat the meat with the seasonings. Cover the bowl with plastic wrap and refrigerate until you are ready to use it. Preheat the oven to 375 degrees Fahrenheit (190 degrees Celsius) and grease the inside of the loaf pan with nonstick cooking spray. Cut the beef into bite-sized pieces. Scoop the stuffing mixture into the center of each piece of beef. Sprinkle the breadcrumbs over the filling. Bake for 20 to 25 minutes, or until the top is golden brown. Serve warm.